Construction of Indole- and Isoquinoline-fused Nitrogen-containing Heterocycles through Copper-catalyzed Multi-component Reaction
نویسندگان
چکیده
منابع مشابه
Construction of indole- and isoquinoline-fused nitrogen-containing heterocycles through copper-catalyzed multi-component reaction.
A copper-catalyzed synthesis of 2-(aminomethyl)indole through domino three-component coupling-cyclization has been developed. This reaction proceeds through Mannich-type coupling of 2-ethynylanilines, aldehydes, and secondary amines, followed by hydroamination. This indole formation was applicable to the synthesis of 4-methylene-2,3,4,9-tetrahyro-1H-pyrido[3,4-b]indoles and 5,6,7,8-tetrahydrobe...
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CuO/AB was found to be a simple and efficient catalyst for the N-arylation of a variety of nitrogen-containing heterocycles, giving the products in excellent yields.
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Relatively mild and highly efficient CuI-catalyzed N-arylation procedures for nitrogen-containing heterocycles (e.g., imidazoles, benzimidazoles, pyrroles, pyrazoles, indoles, triazoles, etc.) with aryl and heteroaryl halides have been developed. The protocols can be performed easily and tolerate a number of functional groups, such as ester, nitrile, nitro, ketone, free hydroxyl, and free prima...
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Nitrogen heterocycles are abundant in natural products and pharmaceuticals. An emerging interest among synthetic chemists is to use C-H functionalization to construct the nitrogen-containing core of these heterocycles. The following article will provide a brief overview of this concept with respect to the type of C-H bond functionalized.
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Luminescence is now well established as a sensitive and selective technique for trace analysis of environmental samples.1 In pharmaceutical analysis, however, its frequency of use is reduced. This may be a result of the current ascendancy of high-performance liquid chromatography (HPLC) and the broad band width, featureless luminescence spectra of drug components. In addition, for formulated ph...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2010
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.130.925